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Meningioma Lawsuit: Brain Tumor Claims Linked to Depo-Provera
If you were diagnosed with a meningioma brain tumor and have a history of Depo-Provera injections, you may be entitled to compensation. A landmark BMJ study found a 5.6x increased meningioma risk from prolonged Depo-Provera use.
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What Is the Meningioma Lawsuit?
The meningioma lawsuit — formally known as MDL 3140 — is a federal multidistrict litigation filed against Pfizer, the manufacturer of Depo-Provera (medroxyprogesterone acetate). Plaintiffs allege that prolonged use of Depo-Provera caused them to develop meningioma brain tumors, and that Pfizer concealed or downplayed this risk for decades.
As of April 2026, more than 3,099 cases have been filed in MDL 3140, consolidated in the Northern District of Florida before Judge M. Casey Rodgers. The case count is growing approximately 47% per month, making this one of the fastest-growing pharmaceutical litigations in the country.
Key Facts: Meningioma Lawsuit
- MDL 3140 — Northern District of Florida, Judge M. Casey Rodgers
- 3,099+ cases filed as of April 2026
- 5.6x increased meningioma risk from 1+ year Depo-Provera use (BMJ 2024)
- FDA added meningioma warning to Depo-Provera label — December 2025
- No settlement yet — first bellwether trial December 2026
- No upfront cost — attorneys work on contingency
What Is a Meningioma?
A meningioma is a tumor that forms in the meninges — the protective membranes surrounding the brain and spinal cord. Although classified as typically non-cancerous (benign), meningiomas cause severe symptoms based on their size and location:
- Persistent, worsening headaches
- Vision changes, double vision, or vision loss
- Cognitive problems, memory impairment, personality changes
- Seizures
- Hearing loss or tinnitus
- Weakness or numbness in limbs
Many meningiomas require neurosurgery, stereotactic radiosurgery, or ongoing radiation therapy. Some are inoperable due to their location near critical brain structures.
The Link Between Depo-Provera and Meningioma
The connection between injectable medroxyprogesterone and meningioma has been building for over a decade, reaching a tipping point with a major 2024 study:
The 2024 BMJ Study
A landmark study published in the British Medical Journal by Peyre et al. analyzed health records of hundreds of thousands of women in France. The findings were unambiguous: women who used injectable medroxyprogesterone for one year or more had a 5.6 times greater risk of developing intracranial meningiomas. The risk was dose-dependent — longer use correlating with higher risk.
Why Medroxyprogesterone Is Different
Meningiomas express progesterone receptors. Medroxyprogesterone acetate (the active ingredient in Depo-Provera) is a synthetic progestin that binds powerfully to these receptors. Unlike oral contraceptives metabolized daily, a single Depo-Provera injection maintains elevated hormone levels for three full months, creating prolonged receptor stimulation that may promote tumor growth.
FDA Action
In December 2025, the FDA required Pfizer to add a meningioma warning to the Depo-Provera label. Plaintiffs argue this warning came more than 30 years after the drug was approved — and that Pfizer had access to the underlying science long before the BMJ study was published.
Do You Qualify for a Meningioma Lawsuit?
Qualifying Criteria
- You received two or more Depo-Provera or generic medroxyprogesterone injections
- You were diagnosed with a meningioma brain tumor (confirmed by MRI, CT, or biopsy)
- You are within your state's statute of limitations (typically 2-3 years from diagnosis)
- You have not already retained a law firm for this specific claim
Note on generic medroxyprogesterone: If you received generic medroxyprogesterone acetate instead of brand-name Depo-Provera, you may still qualify. The active ingredient and risk profile are identical.
Find Out If You Qualify — Free
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Get Your Free Case ReviewWhat Compensation Is Available?
No global settlement has been reached in MDL 3140 as of April 2026. However, based on comparable mass tort litigations and the severity of meningioma injuries, potential compensation may include:
- Medical expenses — neurosurgery, radiation, imaging, ongoing treatment
- Lost wages — income lost during recovery
- Pain and suffering — physical and emotional distress
- Loss of enjoyment of life
- Loss of consortium
The Timeline: What Happens Next
MDL 3140 is currently in the discovery phase. Key upcoming dates:
- December 2026 — First bellwether trial scheduled
- Bellwether outcomes will significantly influence global settlement negotiations
- The MDL continues to grow — now is the time to join to preserve your rights
How to File a Meningioma Lawsuit
- Gather records: Depo-Provera injection history (pharmacy records, insurance claims, doctor notes) and meningioma diagnosis records (MRI reports, surgical records, pathology reports)
- Check your deadline: Every state has a statute of limitations. Check your state here.
- Submit a free case evaluation: Share your information with experienced attorneys for a no-cost review.
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Frequently Asked Questions
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