If Depo-Provera Gave You a Brain Tumor, You Deserve Answers — and Compensation.

What Is the Depo-Provera Meningioma Lawsuit?

Thousands of women across the United States are filing lawsuits against Pfizer, the manufacturer of Depo-Provera, alleging that long-term use of the injectable contraceptive caused them to develop meningioma brain tumors — and that Pfizer knew about the risk but failed to adequately warn patients and doctors.

Depo-Provera (medroxyprogesterone acetate) is a hormonal birth control injection administered every three months. It has been on the market since 1992 and has been used by an estimated 24 million women in the United States.

In 2024, a landmark study published in the British Medical Journal (BMJ) found that women who used injectable medroxyprogesterone for one year or longer had a 5.6 times greater risk of developing intracranial meningiomas compared to women who never used the drug.

In response to mounting evidence, the FDA added a meningioma warning to the Depo-Provera label in December 2025 — more than 30 years after the drug was first approved. Plaintiffs argue this warning came decades too late.

What Is a Meningioma?

A meningioma is a tumor that develops in the meninges — the layers of tissue that surround and protect your brain and spinal cord. While meningiomas are technically classified as non-cancerous (benign) in most cases, the word "benign" is misleading. These tumors can cause serious, life-altering symptoms depending on their size and location:

• Chronic headaches that worsen over time
• Vision changes or loss — blurred vision, double vision, or partial blindness
• Hearing loss or ringing in the ears
• Cognitive impairment — memory problems, difficulty concentrating, personality changes
• Seizures
• Weakness or numbness in the arms or legs
• Speech difficulties

Many meningiomas require neurosurgery to remove — a procedure that carries its own significant risks including infection, bleeding, stroke, and neurological damage. Some tumors are inoperable due to their location, requiring ongoing monitoring and management with radiation therapy.

For many women, a meningioma diagnosis means years of medical treatment, lost wages, diminished quality of life, and ongoing fear of tumor recurrence.

Do You Qualify for a Depo-Provera Lawsuit?

You may be eligible to file a claim if all of the following apply to you:

Important: If you used generic medroxyprogesterone acetate instead of brand-name Depo-Provera, you may still qualify. The active ingredient is the same regardless of whether you received the brand-name or generic version.

The Science: How Depo-Provera Causes Meningiomas

The link between hormonal contraceptives and meningiomas has been studied for decades, but the connection to injectable medroxyprogesterone specifically became impossible to ignore after the 2024 BMJ study.

Here's what the science shows:

The BMJ Study (2024)

Published in the British Medical Journal, this large-scale study analyzed health records of women in France who used various forms of hormonal contraception. The findings were striking:

• Women who used injectable medroxyprogesterone for 1+ year had a 5.6x greater risk of developing intracranial meningiomas
• The risk was dose-dependent — longer use correlated with higher risk
• The risk was specific to medroxyprogesterone, not all hormonal contraceptives

The Biological Mechanism

Meningiomas are known to express progesterone receptors. Medroxyprogesterone acetate — the synthetic progestin in Depo-Provera — binds to these receptors and may stimulate tumor growth. Unlike oral contraceptives that are metabolized daily, injectable medroxyprogesterone creates a sustained, elevated level of the hormone for three months per injection, creating prolonged receptor stimulation.

The FDA Response

In December 2025, the FDA required Pfizer to add a meningioma warning to the Depo-Provera label. Plaintiffs argue this warning came more than 30 years too late — and that Pfizer had access to the underlying scientific data long before the BMJ study was published.

What Is MDL 3140?

All federal Depo-Provera meningioma lawsuits have been consolidated into Multidistrict Litigation No. 3140 (MDL 3140) in the Northern District of Florida, before Judge M. Casey Rodgers.

As of April 2026:

• 3,099+ cases are pending in the MDL
• Case count is growing approximately 47% per month
• The first bellwether trial is scheduled for December 2026
• Pfizer has not yet offered a global settlement

A bellwether trial is a test case used to gauge how juries respond to the evidence. The outcome of the December 2026 trial will significantly influence whether Pfizer moves toward settlement negotiations and at what values.

What Compensation Could You Receive?

No settlements have been reached yet in MDL 3140, so there are no confirmed settlement amounts. However, based on the severity of meningioma injuries and comparable mass tort litigations, potential compensation may include:

• Medical expenses — past and future treatment costs, including neurosurgery, radiation, imaging, and follow-up care
• Lost wages — income lost during treatment and recovery
• Pain and suffering — physical pain, emotional distress, and diminished quality of life
• Loss of consortium — impact on family and marital relationships

Cases involving neurosurgery, multiple meningiomas, or significant neurological impairment are expected to be valued at the higher end of any future settlement tiers.

How to File a Depo-Provera Claim

If you believe you qualify, taking action involves three steps:

Step 1: Gather Your Records

Collect documentation of your Depo-Provera or medroxyprogesterone injection history (pharmacy records, insurance claims, or doctor's records) and your meningioma diagnosis (MRI reports, pathology reports, surgical records).

Step 2: Check Your State's Deadline

Every state has a statute of limitations — a legal deadline after which you can no longer file. Most states allow 2-3 years from diagnosis or discovery of the connection. Check your state's specific deadline.

Step 3: Submit a Free Case Evaluation

Share your information with attorneys experienced in Depo-Provera litigation for a free, no-obligation review of your potential claim. There is no cost to you — attorneys in these cases work on contingency, meaning they only get paid if you receive compensation.

Frequently Asked Questions